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KMID : 0191120150300121815
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Journal of Korean Medical Science
2015 Volume.30 No. 12 p.1815 ~ p.1820
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Clinical Features of Drug-induced Liver Injury According to Etiology
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Lee Byoung-Moo
Lee Woong-Cheul
Jang Jae-Young
Ahn Pyoung
Kim Jin-Nyoung
Jeong Soung-Won
Park Eui-Ju
Lee Sae-Hwan
Kim Sang-Gyune
Cha Sang-Woo
Kim Young-Seok
Cho Young-Deok
Kim Hong-Soo
Kim Boo-Sung
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Abstract
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Drug-induced liver injury (DILI) is an increasingly common cause of acute hepatitis. We examined clinical features and types of liver injury of 65 affected patients who underwent liver biopsy according DILI etiology. The major causes of DILI were the use of herbal medications (43.2%), prescribed medications (21.6%), and traditional therapeutic preparations and dietary supplements (35%). DILI from herbal medications, traditional therapeutic preparations, and dietary supplements was associated with higher elevations in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels than was DILI from prescription medications. The types of liver injury based on the R ratio were hepatocellular (67.7%), mixed (10.8%), and cholestatic (21.5%). Herbal medications and traditional therapeutic preparations were more commonly associated with hepatocellular liver injury than were prescription medications (P = 0.002). Herbal medications and traditional therapeutic preparations induce more hepatocellular DILI and increased elevations in AST and ALT than prescribed medications.
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KEYWORD
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Drug-induced Liver Injury, Hepatotoxicity, Etiology, Plants, Medicinal, Traditional Therapy, Prescribed Medicines
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